Laboratory of Catalytic Processes Kinetics

RESEARCH FIELDS:

The development, probing and application of the kinetic research methods for the complex catalytic processes accompanied by the formation, deactivation, and reactivation of active catalyst

The investigations of the mechanisms of Pd-catalyzed reactions of aryl halides coupling with different nucleophiles (alkenes, alkynes, arylboronic compounds, and heteroaromatics) using the set of the developed kinetic approaches)

ONGOING PROJECTS:

Grant of Russian Science Foundation No.19-13-00051

Grant of Russian Science Foundation No. 19-73-10004

Grant of Russian Science Foundation No. 21-73-00137

State-funded Project by the Ministry of Science and Higher Education

(Agreement № № 075-03-2020-176/3; code at the Parus 8 System FZZE-2020-0022)

“Establishing of fundamental aspects of prospective Suzuki-Miyaura reaction with available non-reactive substrates using novel kinetic investigation methods”, 2019-2021, supervisor Schmidt A.F.

“Development of effective 'ligand-free' catalytic systems for synthetically important Mizoroki-Heck reaction with nonreactive aryl chlorides based on the results of the complex of kinetic study”, 2019-2022, supervisor Kurokhtina A.A.

“Investigation of the mechanism of substrates activation under synthetically important Sonogashira reaction conditions aimed at the development of simple effective "ligand-free" catalytic systems”, 2021-2022, supervisor Larina E.V.

“Experimental and Theoretical Research on Structure, Reactivity of Catalytic and Physicochemical Properties as well as on Methods for Synthesis Pd-, Ni, and Cr-containing Metal Complexes, Nanoparticles, Polymers, and Materials: New Catalytic Systems, Functionalized Polymeric and Bimetallic Materials, Including Amphiphilic, Biocompatible, and Hybrid”, supervisor Schmidt A.F.

ACHIEVED OUTCOMES:

The kinetic methods for the investigation of the mechanisms of complex catalytic reactions have been developed based on the measurements of the differential selectivity of the catalytic systems. The methods have several advantages over the traditional kinetic methods that use the reaction rate/catalytic activity as the main parameter. Using the developed methods, the direct experimental evidences for the mechanistic hypotheses have been found for the synthetically important Heck reaction and its modifications, Suzuki and Sonogashira reactions, and direct arylation of heteroaromatics. The obtaining of such proofs was impossible earlier using traditional methods of chemical kinetics.