Stress-physiology of Baikal Endemic Organisms under the Global Climate Change

Fields of study: Environmental Studies, Stress Physiology, Toxicology, Biochemistry

Molecular Genetic Studies of Baikal Endemic Amphipods 

Fields of study: Molecular Biology, Genetics, Transcriptomics, Proteomics

Sensor Technologies in Biological Applications

Fields of study: Biosensorics, Fluorescence Microscopy, Molecular Biology, Environmental Studies

Pathological Conditions of Fish and Search for Biologically Active Compounds in Their Parasites

Fields of study:  Parasitology, Histology, Immunology, Biophotonics, Transcriptomics

Long-term Ecological Monitoring of Lake Baikal - "Point №1"

Fields of study: Environmental Studies, Biomonitoring, Systematics, Microscopy

Stress-physiology of Baikal Endemic Organisms under the Global Climate Change

Bedulina D., Drozdova P., Gurkov A., M.Bergen, P.F. Stadler, T. Luckenbach, M. Timofeyev, S. Kalkhof. . Proteomics reveals sex-specific heat shock response of Baikal amphipod Eulimnogammarus cyaneus, Science of The Total Environment, Volume 763, 143008 (2021) (Q1, IF 7.9).

Vereshchagina, K., Kondrateva, E., Mutin, A. et al. Low annual temperature likely prevents the Holarctic amphipod Gammarus lacustris from invading Lake Baikal. Sci Rep 11, 10532 (2021). (Q1, IF 3.998).

Pekkoeva, S.N., Voronin, V.P., Shatilina, Z.M. Madyarova E.V.,  Axenov-Gribanov D.V.,  Shirokova Y.A., Timofeyev M.A., Nemova N.N., Murzina S.A. Lipid and fatty acid composition of scavenging amphipods Ommatogammarus spp. from different depths of lake Baikal. Limnology (2021). (Q2, IF 1.625).

Jakob, L., Vereshchagina, K.P., Tillmann, A. et al. Thermal reaction norms of key metabolic enzymes reflect divergent physiological and behavioral adaptations of closely related amphipod species. Sci Rep 11, 4562 (2021). (Q1, IF 3.998).

Lubyaga et al. "Invader amphipods Gmelinoides fasciatus (Stebbing, 1899) inhabiting distant waterbodies demonstrate differences in tolerance and energy metabolism under elevated temperatures" Journal of Great Lakes Research (IF 2.17, Q1).

Shatilina Zh., P. Drozdova, D. Bedulina, L. Rivarola-Duarte, S. Schreiber, C. Otto, F. Jühling, S. Aulhorn, W. Busch, Y. Lubyaga, E. Kondrateva, T. Pobezhimova, L. Jakob, M. Lucassen, F. J. Sartoris, J. Hackermüller, H.O. Pörtner, P.F. Stadler, T. Luckenbach (2020) Transcriptome-level effects of the model organic pollutant phenanthrene and its solvent acetone in three amphipod species. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 33,100630. 

Axenov-Gribanov, D. V., Bedulina, D. S., Shirokova, Y. A., Emshanova, V. A., Lubyaga, Y. A., Vereshchagina, K. P., Saranchina, A. E., Pobezhimova, T. P., & Timofeyev, M. A. (2019). Diet influence on mechanisms of non-specific stress-response in Baikal endemic amphipod species during long-term laboratory exposure, Crustaceana, 92(11-12), 1349-1368.

Vereshchagina K.P., Kondrateva E.S., Axenov-Gribanov D.V., Shatilina Zh.M.,Khomich A.S., Bedulina D.S., Zadereev E. S., Timofeyev M.A. (2018) Nonspecific stress response to temperature increase in Gammarus lacustris Sars with respect to oxygen-limited thermal tolerance concept. PeerJ 6:e5571.

Molecular Genetic Studies of Baikal Endemic Amphipods 

Lipaeva, P., Vereshchagina, K., Drozdova, P., Jakob, L., Kondrateva, E., Lucassen, M., Bedulina, D., Timofeyev, M., Stadler, P., & Luckenbach, T. (2021). Different ways to play it cool: Transcriptomic analysis sheds light on different activity patterns of three amphipod species under long-term cold exposure. Molecular Ecology, 00, 1– 17. https://doi.org/10.1111/mec.16164 (Q1, IF 6.1).

Drozdova, P., Kizenko, A., Saranchina, A. et al. The diversity of opsins in Lake Baikal amphipods (Amphipoda: Gammaridae). BMC Ecol Evo 21, 81 (2021). (Q1, IF 3.045).

Drozdova P, Saranchina A, Morgunova M, Kizenko A, Lubyaga Y, Baduev B, Timofeyev M. 2020. The level of putative carotenoid-binding proteins determines the body color in two species of endemic Lake Baikal amphipods. PeerJ 8:e9387 (Q1, IF 2.35).

Drozdova, P., Madyarova, E., Dimova, M., Gurkov, A., Vereshchagina, K., Adelshin, R., Timofeyev, M., The diversity  of  microsporidian  parasites  infecting  the  Holarctic  amphipod Gammaruslacustris  from  the  Baikal  region  is  dominated  by  the  genus Dictyocoela, Journal  of  Invertebrate  Pathology (2020).

P.B. Drozdova, Y.A. Barbitoff, M.V. Belousov, R.K. Skitchenko, T.M. Rogoza, J.Y. Leclercq, A.V. Kajava, A.G. Matveenko, G.A. Zhouravleva, S.A. Bondarev (2020) Estimation of amyloid aggregate sizes with semi-denaturing detergent agarose gel electrophoresis and its limitations, Prion, 14:1, 118-128.

Drozdova P., Rivarola-Duarte L., D. Bedulina, D. Axenov-Gribanov, S. Schreiber, A. Gurkov, Zh. Shatilina, K. Vereshchagina, Y. Lubyaga, E. Madyarova, C. Otto, F. Jühling, W. Busch, L. Jakob, M. Lucassen, F. J. Sartoris, J. Hackermüller, S. Hoffmann, H.O. Pörtner, T. Luckenbach, M.Timofeyev, P.F. Stadler (2019) Comparison between transcriptomic responses to short-term stress exposures of a common Holarctic and endemic Lake Baikal amphipods. BMC Genomics. Volume 20, Article number: 712.

Drozdova, D. Bedulina, E. Madyarova, L. Rivarola-Duarte, S. Schreiber, P. F. Stadler, T. Luckenbach, M. Timofeyev (2019) "Description of strongly heat-inducible heat shock protein 70 transcripts from Baikal endemic amphipods", Scientific reports, 9, 8907.

Dimova M., Madyarova E., Gurkov A., Drozdova P., Lubyaga Y., Kondrateva E., Adelshin R., Timofeyev M.  Genetic diversity of Microsporidia in the circulatory system of endemic amphipods from different locations and depths of ancient Lake Baikal. 2018.  PeerJ 6:e5329.

Bowman, L. L., Kondrateva, E. S., Timofeyev, M. A. and Yampolsky, L. Y. (2018), Temperature gradient affects differentiation of gene expression and SNP allele frequencies in the dominant Lake Baikal zooplankton species. Molecular ecology.  doi:10.1111/mec.14704.

Sensor Technologies in Biological Applications

Shchapova, E.; Nazarova, A.; Gurkov, A.; Borvinskaya, E.; Rzhechitskiy, Y.; Dmitriev, I.; Meglinski, I.; Timofeyev, M. Application of PEG-Covered Non-Biodegradable Polyelectrolyte Microcapsules in the Crustacean Circulatory System on the Example of the Amphipod Eulimnogammarus verrucosus. Polymers, 2019, 11, 1246.

Gurkov, L. Rivarola-Duarte, D. Bedulina, I. Fernández Casas, H. Michael, P. Drozdova, A. Nazarova, E. Govorukhina, M. Timofeyev, P. F. Stadler, T. Luckenbach (2019) "Indication of ongoing amphipod speciation in Lake Baikal by genetic structures within endemic species". BMC Evolutionary Biology. 19:138.

Gurkov, A., Borvinskaya, E., Shchapova, E., Timofeyev, M.  Restraining small decapods and amphipods for in vivo laboratory studies (2018) Crustaceana, 91 (5), pp. 517-525.

Gurkov A, Sadovoy A, Shchapova E, Teh C, Meglinski I, Timofeyev M (2017) Microencapsulated fluorescent pH probe as implantable sensor for monitoring the physiological state of fish embryos. PLoS ONE12(10): e0186548.

Borvinskaya E., Gurkov A., Shchapova E., Baduev B., Shatilina Zh, Sadovoy A., Meglinski I., Timofeyev M. Parallel in vivo monitoring of pH in gill capillaries and muscles of fishes using microencapsulated biomarkers.  Biology Open 2017 6: 673-677.

Gurkov A.,  Shchapova E., Bedulina D., Baduev B., Borvinskaya E., Meglinski I., Timofeyev M. (2016) Remote in vivo stress assessment of aquatic animals with microencapsulated biomarkers for environmental monitoring. Scientific Reports, 6, 36427.

Pathological Conditions of Fish and Search for Biologically Active Compounds in Their Parasites

Borvinskaya E, Gurkov A, Shchapova E, Mutin A, Timofeyev M. 2021. Histopathological analysis of zebrafish after introduction of non-biodegradable polyelectrolyte microcapsules into the circulatory system. PeerJ 9:e11337 (Q2, IF 2.38).

Kochneva A. P. Drozdova, E. Borvinskaya. The first transcriptomic resource for the flatworm Triaenophorus nodulosus (Cestoda: Bothriocephalidea), a common parasite of holarctic freshwater fish. Marine genomics. – 2019.  doi.: 10.1016/j.margen.2019.100702Get.

Borvinskaya, E., Gurkov, A., Shchapova, E., Karnaukhov, D., Sadovoy, A., Meglinski, I., Timofeyev, M. Simple and Effective Administration and Visualization of Microparticles in the Circulatory System of Small Fishes Using Kidney Injection. J. Vis. Exp. (136), e57491, doi:10.3791/57491 (2018).

Borvinskaya, E., Gurkov, A., Shchapova, E., Baduev, B., Meglinski, I., Timofeyev, M. Distribution of PEG-coated hollow polyelectrolyte microcapsules after introduction into the circulatory system and muscles of zebrafish (2018) Biology Open, 7 (1), статья № bio030015.

Borvinskaya E., Gurkov A., Shchapova E., Baduev B., Meglinski I., Timofeyev M.  Distribution of PEG-coated hollow polyelectrolyte microcapsules after introduction into the circulatory system and muscles of zebrafish. Biology Open 2018. 7: bio030015.

Long-term Ecological Monitoring of Lake Baikal - "Point №1"

Meyer, M.F., Ozersky, T., Woo, K.H., Shchapov, K., Galloway, A.W.E., Schram, J.B., Snow, D.D., Timofeyev, M.A., Karnaukhov, D.Y., Brousil, M.R. and Hampton, S.E. (2021), A unified dataset of colocated sewage pollution, periphyton, and benthic macroinvertebrate community and food web structure from Lake Baikal (Siberia). Limnology and Oceanography Letters (Q1, IF 7.8).

Kraemer, B.M., Pilla, R.M., Woolway, R.I... Silow, E.A.... Timofeyev, M.A... et al. Climate change drives widespread shifts in lake thermal habitat. Nature Climate Change (2021).  (Q1, IF 20.893)

Carrea L., R. I. Woolway, C. J. Merchant, M. T. Dokulil, C. L. DeGasperi, E. de Eyto, S. Kelly, R.S. La Fuente, W. Marszelewski, L. May, A. M. Paterson, M. Pulkkanen, J. A. Rusak, O. Rusanovskaya, S. G. Schladow, M. Schmid, S. V. Shimaraeva, E. A. Silow, M. A. Timofeyev, P. Verburg, S. Watanabe, and G. A. Weyhenmeyer, 2020: Lake surface temperature [in “State of the Climate in 2019”]. Bull. Amer. Meteor. Soc., 101 (8), Si–S429 (Q1, IF - 9.384).

Ozersky T., Nakov T., Hampton S., Rodenhouse N., Shchapov K., Woo K., Wright K., Pislegina E., Izmesteva L., Silow E., Timofeyev M., Moore M. “Hot and sick? Impacts of warming and a parasite on the dominant zooplankter of Lake Baikal”, Limnology and Oceanography, 2020, V.65, 11, P. 2772-2786 (IF 4.325, Q1).

M.V. Moore, B.T. Jr. De Stasio, K.N. Huizenga, E.A. Silow. Trophic coupling of the microbial and the classical food web in Lake Baikal, Siberia. Freshwater Biology. – 2019. – V. 64, N 1. – P. 138-151. DOI: 10.1111/fwb.13201.

M.V. Moore, B.T. De Stasio Jr., K.N. Huizenga, E.A. Silow (2018) Trophic coupling of the microbial and the classical food web in Lake Baikal, Siberia. Freshwater Biology. DOI: 10.1111/fwb.13201

Hampton S.E,…, Silow E.A.,…, Timofeyev M.A., et al. Ecology under lake ice. Ecology letters, (2017) 20: 98–111.

Timofeyev M.A., Silow E.A., Mackay A.W., Moore M.V., Likens G.E. (2016) Safeguarding the world’s largest lake. Nature. Vol.538, № 7623, pp. 41.

Sharma, S… L.R. Izmest’eva, E.A. Silow… et al. A global database of lake surface temperatures collected by in situ and satellite methods from 1985–2009. Scientific Data (Nature Publishing Group) 2:150008 doi: 10.1038/sdata.2015.8.